Archana S
Sri Ramachandra University, India
Title: Pregnancy outcome in fresh and frozen embryo transfer in women with high estradiol levels
Biography
Biography: Archana S
Abstract
Exogenous elevation of serum estradiol shortly after the time of ovulation is known to reduce the endometrial receptivity in natural cycle. High serum estradiol may affect the synthesis and secretion of glycogen by endometrial epithelial cells. Studies on endometrial morphology, biochemistry and endometrial genomic pattern at the time of implantation showed that high estradiol may negatively affect the endometrial receptivity during infertility treatment. High estradiol is one of the contributing factors for OHSS. Controlled Ovarian Hyperstimulation (COH) creates a supraphysiologic environment which affects endometrial receptivity. Frozen embryo transfer avoids supraphysiological environment which alters the endometrial receptivity. Endometrial development can be controlled precisely in frozen embryo transfer cycle than in COH with gonadotropins.